Acylation of Naturally Occurring and Synthetic 1-Deoxysphinganines by Ceramide Synthase

@article{Humpf1998AcylationON,
  title={Acylation of Naturally Occurring and Synthetic 1-Deoxysphinganines by Ceramide Synthase},
  author={Hans-Ulrich Humpf and Eva M. Schmelz and Filmore I. Meredith and Hubert W. Vesper and Teresa R. Vales and Elaine Wang and David S. Menaldino and Dennis C. Liotta and Alfred H. Merrill},
  journal={The Journal of Biological Chemistry},
  year={1998},
  volume={273},
  pages={19060 - 19064}
}
Fumonisin B1 (FB1) is the predominant member of a family of mycotoxins produced byFusarium moniliforme (Sheldon) and related fungi. Certain foods also contain the aminopentol backbone (AP1) that is formed upon base hydrolysis of the ester-linked tricarballylic acids of FB1. Both FB1 and, to a lesser extent, AP1 inhibit ceramide synthase due to structural similarities between fumonisins (as 1-deoxy-analogs of sphinganine) and sphingoid bases. To explore these structure-function relationships… Expand
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