Acylation of L-asparaginase with total retention of enzymatic activity.


Acylation of L-asparaginase (L-asparagine amidohydrolase, EC with complete retention of catalytic activity was achieved. Several parameters of the acylation method, based on the binding of palmitoyl residues to epsilon-NH2 groups of protein, were optimized. The correlation between the acylation degree of L-asparaginase and the retention of… (More)


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