• Medicine
  • Published in Gut 2006

Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect.

@article{Neary2006AcylatedGS,
  title={Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect.},
  author={Nicola Marguerite Neary and Maralyn Druce and Caroline J. Small and Stephen R Bloom},
  journal={Gut},
  year={2006},
  volume={55 1},
  pages={
          135
        }
}
We were interested to read the article of Asakawa et al ( Gut 2005; 54 :18–24) which reported that intracerebroventricular and peripheral administration of desacylated ghrelin inhibited food intake in mice in the fasted state. Acylated ghrelin (AG) has a unique biological structure with an acyl side chain on the third amino acid residue. AG is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a)1 and stimulates feeding and growth hormone release. In contrast, desacylated… CONTINUE READING

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