Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin.

Abstract

Bacterial resistance to beta-lactam antibiotics is a serious problem limiting current clinical therapy. The most common form of resistance is the production of beta-lactamases that inactivate beta-lactam antibiotics. Toho-1 is an extended-spectrum beta-lactamase that has acquired efficient activity not only to penicillins but also to cephalosporins… (More)

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Cite this paper

@article{Shimamura2002AcylintermediateSO, title={Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin.}, author={Tatsuro Shimamura and Akiko Shimizu Ibuka and Shinya Fushinobu and Takayoshi Wakagi and Masaji Ishiguro and Yoshikazu Ishii and Hiroshi Matsuzawa}, journal={The Journal of biological chemistry}, year={2002}, volume={277 48}, pages={46601-8} }