Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro.

@article{BarkerCarlson2002AcylenzymeCB,
  title={Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro.},
  author={Karen Barker-Carlson and Daniel A Lawrence and Bradford S. Schwartz},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 49},
  pages={46852-7}
}
The serine protease tissue-type plasminogen activator (t-PA) initiates the fibrinolytic protease cascade and plays a significant role in motor learning, memory, and neuronal cell death induced by excitotoxin and ischemia. In the fibrinolytic system, the serpin PAI-1 negatively regulates the enzymatic activity of both single-chain and two-chain t-PA (sct-PA and tct-PA). In the central nervous system, neuroserpin (NSP) is a serpin thought to regulate t-PA enzymatic activity. We report that… CONTINUE READING

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