Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.

@article{Linton2002AcylDA,
  title={Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.},
  author={Steven D. Linton and Donald Steven Karanewsky and Robert J. Ternansky and Joe C. Wu and Brian Pham and Lalitha Kodandapani and Robert K. Smidt and Jos{\'e}-Luis D{\'i}az and Lawrence C. Fritz and Kevin James Tomaselli},
  journal={Bioorganic & medicinal chemistry letters},
  year={2002},
  volume={12 20},
  pages={
          2969-71
        }
}
Parallel synthesis was used to explore the SAR of a peptidomimetic caspase inhibitor. The most potent compound had nanomolar activity against caspases 1, 3, 6, 7, and 8. 

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