Acyl derivatives of demethylpenclomedine, an antitumor-active, non-neurotoxic metabolite of penclomedine

@article{Struck2001AcylDO,
  title={Acyl derivatives of demethylpenclomedine, an antitumor-active, non-neurotoxic metabolite of penclomedine},
  author={R. Struck and A. Tiwari and H. Friedman and Steven Keir and L. Morgan and W. Waud},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2001},
  volume={48},
  pages={47-52}
}
  • R. Struck, A. Tiwari, +3 authors W. Waud
  • Published 2001
  • Medicine
  • Cancer Chemotherapy and Pharmacology
  • Abstract. Purpose: The purpose of this investigation was to compare the antitumor activities of a series of acyl derivatives of 4-demethylpenclomedine (DM-PEN), the major plasma metabolite of penclomedine (PEN) observed to be an active antitumor agent in vivo and non-neurotoxic in a rat model with that of DM-PEN. Methods: Acyl derivatives were prepared from DM-PEN and evaluated in vivo against human MX-1 breast tumor xenografts implanted subcutaneously (s.c.) or intracerebrally (i.c.). Several… CONTINUE READING
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