Acyl chain-dependent effect of lysophosphatidylcholine on endothelial prostacyclin production.

@article{Riederer2010AcylCE,
  title={Acyl chain-dependent effect of lysophosphatidylcholine on endothelial prostacyclin production.},
  author={Monika Riederer and Pauli J. Ojala and Andelko Hrzenjak and Wolfgang F. Graier and Roland Malli and Michaela Tritscher and Martin Hermansson and Bernhard Watzer and Horst Schweer and Gernot Desoye and Akos Heinemann and Sa{\vs}a Frank},
  journal={Journal of lipid research},
  year={2010},
  volume={51 10},
  pages={2957-66}
}
Previously we identified palmitoyl-lysophosphatidylcholine (16:0 LPC), linoleoyl-LPC (18:2 LPC), arachidonoyl-LPC (20:4 LPC), and oleoyl-LPC (18:1 LPC) as the most prominent LPC species generated by the action of endothelial lipase (EL) on high-density lipoprotein. In the present study, the impact of those LPC on prostacyclin (PGI(2)) production was examined in vitro in primary human aortic endothelial cells (HAEC) and in vivo in mice. Although 18:2 LPC was inactive, 16:0, 18:1, and 20:4 LPC… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…