Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.

@article{Moffat2014AcylCoATF,
  title={Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.},
  author={Cynthia Moffat and Lavesh Bhatia and T. Nguyen and Peter Lynch and Miao Wang and Dongning Wang and Olga Ilkayeva and Xianlin Han and Matthew D Hirschey and Steven M Claypool and Erin L. Seifert},
  journal={Journal of lipid research},
  year={2014},
  volume={55 12},
  pages={2458-70}
}
Acyl-CoA thioesterase (Acot)2 localizes to the mitochondrial matrix and hydrolyses long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxi-dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is unknown. Using a model of adenoviral Acot2 overexpression in mouse liver (Ad-Acot2), we show that Acot2 increases the utilization of FA substrate during the daytime in ad libitum-fed mice, but the nighttime switch to carbohydrate… CONTINUE READING
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