Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I.

@article{Nouws2010AcylCoAD9,
  title={Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I.},
  author={J. F. M. Nouws and Leo G. J. Nijtmans and Sander M. Houten and Mari{\"e}l A. M. van den Brand and Martijn A. Huynen and Hanka Venselaar and Saskia J G Hoefs and Jolein Gloerich and Jonathan B. Kronick and Timothy Hutchin and Peter H G M Willems and Richard J T Rodenburg and Ronald J. A. Wanders and Lambert P. van den Heuvel and Jan A.M. Smeitink and Rutger O. Vogel},
  journal={Cell metabolism},
  year={2010},
  volume={12 3},
  pages={
          283-94
        }
}
Acyl-CoA dehydrogenase 9 (ACAD9) is a recently identified member of the acyl-CoA dehydrogenase family. It closely resembles very long-chain acyl-CoA dehydrogenase (VLCAD), involved in mitochondrial beta oxidation of long-chain fatty acids. Contrary to its previously proposed involvement in fatty acid oxidation, we describe a role for ACAD9 in oxidative phosphorylation. ACAD9 binds complex I assembly factors NDUFAF1 and Ecsit and is specifically required for the assembly of complex I… CONTINUE READING

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