Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae.

@article{Faergeman2004AcylCoAbindingPA,
  title={Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae.},
  author={Nils Joakim Faergeman and S\oren Feddersen and J. K. Christiansen and Morten Krog Larsen and Roger Schneiter and Christian Ungermann and Kudzai E Mutenda and Peter Roepstorff and Jens Knudsen},
  journal={The Biochemical journal},
  year={2004},
  volume={380 Pt 3},
  pages={907-18}
}
In the present study, we show that depletion of acyl-CoA-binding protein, Acb1p, in yeast affects ceramide levels, protein trafficking, vacuole fusion and structure. Vacuoles in Acb1p-depleted cells are multi-lobed, contain significantly less of the SNAREs (soluble N -ethylmaleimide-sensitive fusion protein attachment protein receptors) Nyv1p, Vam3p and Vti1p, and are unable to fuse in vitro. Mass spectrometric analysis revealed a dramatic reduction in the content of ceramides in whole-cell… CONTINUE READING

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Structure, function and phylogeny of acyl-CoA binding protein

  • S. Mandrup, N. J. Færgeman, J. Knudsen
  • In Cellular Proteins and their Fatty Acids in…
  • 2003

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