Acyclovir with and without prednisone for the treatment of herpes zoster. A randomized, placebo-controlled trial. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group.

@article{Whitley1996AcyclovirWA,
  title={Acyclovir with and without prednisone for the treatment of herpes zoster. A randomized, placebo-controlled trial. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group.},
  author={Ryan J. Whitley and Halko Weiss and John W. Gnann and Steve K. Tyring and Gregory J. Mertz and Peter George Pappas and Christine Schleupner and Frederick G. Hayden and Jurgen Wolf and Seng Jaw Soong},
  journal={Annals of internal medicine},
  year={1996},
  volume={125 5},
  pages={
          376-83
        }
}
Herpes zoster results from the reactivation of latent varicella-zoster virus located in the dorsal root ganglia. The condition is common in elderly and immunocompromised patients. Although herpes zoster is not a reportable disease, an estimated 300 000 to 500 000 cases occur annually in the United States [1]. In immunocompetent persons, the most notable manifestations are acute neuritis and persistent pain, traditionally called postherpetic neuralgia. Recent clinical trials of acyclovir [2-5… CONTINUE READING
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