Acyclovir-resistant varicella zoster virus infection after chronic oral acyclovir therapy in patients with the acquired immunodeficiency syndrome (AIDS).

@article{Jacobson1990AcyclovirresistantVZ,
  title={Acyclovir-resistant varicella zoster virus infection after chronic oral acyclovir therapy in patients with the acquired immunodeficiency syndrome (AIDS).},
  author={Mark A. Jacobson and Timothy G. Berger and Senih H Fikrig and Paul R Becherer and John W Moohr and Sylvia C Stanat and K. Biron},
  journal={Annals of internal medicine},
  year={1990},
  volume={112 3},
  pages={187-91}
}
Four patients with human immunodeficiency virus (HIV) infection who received chronic oral acyclovir therapy for suppression of recurrent varicella zoster or herpes simplex virus infection developed persistent disseminated hyperkeratotic papules that failed to heal with intravenous or high-dose oral acyclovir therapy. Varicella zoster virus, resistant to acyclovir in vitro, was isolated from skin lesions of all four patients. Three patients were adults in whom the acquired immunodeficiency… CONTINUE READING
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