Acyclovir inhibition of viral DNA chain elongation in herpes simplex virus-infected cells.

@article{McGuirt1982AcyclovirIO,
  title={Acyclovir inhibition of viral DNA chain elongation in herpes simplex virus-infected cells.},
  author={P V McGuirt and Phillip A. Furman},
  journal={The American journal of medicine},
  year={1982},
  volume={73 1A},
  pages={67-71}
}
The effect of acyclovir on DNA synthesized in HSV-1-infected cells was examined. Viral DNA synthesis was significantly reduced in the presence of 10 microM acyclovir monitored by cRNA-DNA hybridization and isopycnic centrifugation in cesium chloride. DNA synthesized in infected cells in the presence of acyclovir appeared to be chain-terminated when evaluated by rate zonal centrifugation in alkaline sucrose. Cellular DNA synthesis in actively replicating uninfected cells in the presence of… CONTINUE READING