Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.

@article{Gray2010AcyclovirAT,
  title={Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.},
  author={Richard T. Gray and David Peter Wilson},
  journal={The New England journal of medicine},
  year={2010},
  volume={362 5},
  pages={427-39}
}
BACKGROUND Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital levels of HIV-1. Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1. METHODS We conducted a randomized, placebo-controlled trial of… CONTINUE READING
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