Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.

@article{Celum2010AcyclovirAT,
  title={Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.},
  author={C. Celum and A. Wald and J. Lingappa and A. Magaret and R. S. Wang and N. Mugo and A. Mujugira and J. Baeten and J. Mullins and J. Hughes and E. Bukusi and C. Cohen and E. Katabira and A. Ronald and J. Kiarie and C. Farquhar and G. Stewart and J. Makhema and M. Essex and E. Were and K. Fife and G. de Bruyn and G. Gray and J. McIntyre and R. Manongi and S. Kapiga and D. Coetzee and S. Allen and M. Inambao and K. Kayitenkore and E. Karita and W. Kanweka and S. Delany and H. Rees and B. Vwalika and W. Stevens and M. Campbell and K. Thomas and R. Coombs and R. Morrow and W. Whittington and M. McElrath and L. Barnes and R. Ridzon and L. Corey},
  journal={The New England journal of medicine},
  year={2010},
  volume={362 5},
  pages={
          427-39
        }
}
BACKGROUND Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital levels of HIV-1. Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1. METHODS We conducted a randomized, placebo-controlled trial of… Expand
258 Citations

Paper Mentions

Interventional Clinical Trial
The University of Washington has received funding to conduct a proof-of-concept trial to assess the impact of suppression of genital herpes on HIV infectiousness. This study (the… Expand
ConditionsHerpes Simplex, Genital, HIV Infection, Sexually Transmitted Diseases
InterventionDrug
Adherence in HIV type 1 prevention trials.
  • J. Baeten
  • Medicine
  • The Journal of infectious diseases
  • 2010
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Effect of acyclovir on HIV-1 set point among herpes simplex virus type 2-seropositive persons during early HIV-1 infection.
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Reactivation of herpes simplex virus type 2 after initiation of antiretroviral therapy.
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Valacyclovir Decreases Plasma HIV-1 RNA in HSV-2 Seronegative Individuals: A Randomized Placebo-Controlled Crossover Trial.
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Treating HIV infection with drugs for HSV-2 infection?
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Prevention of HIV-1 infection with antiretroviral therapy.
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