Acyclovir-Induced Neurotoxicity: A Case Report and Review of Literature.

  title={Acyclovir-Induced Neurotoxicity: A Case Report and Review of Literature.},
  author={M. A. Chowdhury and Nada Derar and S. Hasan and Bryan T. Hinch and S. Ratnam and R. Assaly},
  journal={American journal of therapeutics},
  volume={23 3},
Neurotoxicity can develop as a side effect of intravenous acyclovir use in patients with renal impairment. It is underreported in clinical practice and often confused with worsening herpes encephalitis. We present a 69-year-old woman with end-stage renal disease on hemodialysis with acyclovir neurotoxicity treated with daily extended hemodialysis sessions. Daily hemodialysis for extended period may shorten the neurotoxicity period and can help with faster return to normal mentation. A high… Expand
A Case Report of Neurotoxicity After Prolonged Doses of Acyclovir in a Patient With Renal Dysfunction
Therapeutic drug monitoring of anti-infective agents in critically ill patients


Severe but reversible neurotoxicity from acyclovir.
Neurotoxicity of acyclovir in patients with end-stage renal failure treated with continuous ambulatory peritoneal dialysis.
Acyclovir-induced neurotoxicity: concentration-side effect relationship in acyclovir overdose.
Hemodialysis removal of acyclovir.
Altered mental status from acyclovir.
High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study.
  • A. Helldén, I. Odar‐Cederlöf, +5 authors L. Ståhle
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2003
Monitoring the safety of antivirals. The example of the acyclovir experience.
  • H. Tilson
  • Medicine
  • The American journal of medicine
  • 1988
Altered mental status from acyclo
  • J Emerg Med
  • 2011