Acyclovir: Discovery, mechanism of action, and selectivity

@article{Elion1993AcyclovirDM,
  title={Acyclovir: Discovery, mechanism of action, and selectivity},
  author={Gertrude Bell Elion},
  journal={Journal of Medical Virology},
  year={1993},
  volume={41}
}
  • G. Elion
  • Published 1993
  • Biology
  • Journal of Medical Virology
The reasons for acyclovir's activity and selectivity in cells infected with HSV or VZV may be summarized as follows: 1. Activation by a HSV- or VZV-specified TK. 2. Greater sensitivity of viral DNA polymerase than of the cellular polymerases to ACV-TP. 3. Inactivation of the viral DNA polymerase, but not the cellular polymerases, by ACV-TP. 4. Chain termination of viral DNA by incorporation of ACV-MP. For the Epstein-Barr virus, which is also sensitive to acyclovir, there is no selective… 

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