Acyclovir: Discovery, mechanism of action, and selectivity
@article{Elion1993AcyclovirDM, title={Acyclovir: Discovery, mechanism of action, and selectivity}, author={Gertrude Bell Elion}, journal={Journal of Medical Virology}, year={1993}, volume={41} }
The reasons for acyclovir's activity and selectivity in cells infected with HSV or VZV may be summarized as follows: 1. Activation by a HSV- or VZV-specified TK. 2. Greater sensitivity of viral DNA polymerase than of the cellular polymerases to ACV-TP. 3. Inactivation of the viral DNA polymerase, but not the cellular polymerases, by ACV-TP. 4. Chain termination of viral DNA by incorporation of ACV-MP. For the Epstein-Barr virus, which is also sensitive to acyclovir, there is no selective…
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