Acyclic retinoid inhibits neointima formation through retinoic acid receptor beta-induced apoptosis.

@article{Kada2007AcyclicRI,
  title={Acyclic retinoid inhibits neointima formation through retinoic acid receptor beta-induced apoptosis.},
  author={Nanae Kada and Toshinori Suzuki and Kiyoharu Aizawa and Takayoshi Matsumura and Naoto Ishibashi and Naomi Suzuki and Norifumi Takeda and Yoshiko Munemasa and Daigo Sawaki and Takashi Ishikawa and Ryozo Nagai},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 7},
  pages={
          1535-41
        }
}
OBJECTIVES Acyclic retinoid (ACR) is a synthetic retinoid with a high safety profile that has been pursued with high expectations for therapeutic use in prevention (recurrence) and treatment of malignancies. With the objective of addressing the therapeutic potential in the cardiovasculature, namely neointima formation, effects of ACR on neointima formation and the involved mechanisms were investigated. METHODS AND RESULTS ACR was administered to cuff-injured mice which showed inhibition of… CONTINUE READING

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