Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

Abstract

Adenylate kinases are involved in the activation of antiviral drugs such as the acyclic phosphonates analogs PMEA and (R)PMPA. We examine the in vitro phosphorylation of PMEA and PMPA bearing a borano- or a H- group on the phosphorus atom. The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 1 and 2… (More)
DOI: 10.1080/15257770801941952

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Cite this paper

@article{Topalis2008AcyclicPN, title={Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.}, author={Dimitri Topalis and Kimberly Alvarez and Karine Barral and H{\'e}l{\'e}ne Munier-Lehmann and B. Schneider and M. Veron and Carlos Tostes Guerreiro and Laurence A. Mulard and Chahrazade El-Amri and Bertrand Canard and Dominique Deville-Bonne}, journal={Nucleosides, nucleotides & nucleic acids}, year={2008}, volume={27 4}, pages={319-31} }