Acyclic nucleoside phosphonates in the chemotherapy of DNA virus and retrovirus infections.

@article{Clercq1997AcyclicNP,
  title={Acyclic nucleoside phosphonates in the chemotherapy of DNA virus and retrovirus infections.},
  author={Erik de Clercq},
  journal={Intervirology},
  year={1997},
  volume={40 5-6},
  pages={295-303}
}
The acyclic nucleoside phosphonates [HPMPC (cidofovir), PMEA (adefovir) and PMPA] have proved to the effective in vitro (cell culture systems) and in vivo (animal models, clinical studies) against a wide variety of DNA virus and retrovirus infections: i.e., HPMPC against herpesvirus (herpes simplex virus type 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, human herpesvirus types 6, 7, and 18), polyoma-, papilloma-, adeno-, and poxvirus (vaccinia virus, molluscum… CONTINUE READING
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