Acyclic cucurbit[n]uril molecular containers enhance the solubility and bioactivity of poorly soluble pharmaceuticals.

@article{Ma2012AcyclicCM,
  title={Acyclic cucurbit[n]uril molecular containers enhance the solubility and bioactivity of poorly soluble pharmaceuticals.},
  author={Da Ma and Gaya K Hettiarachchi and Duc Nguyen and Ben Zhang and James B Wittenberg and Peter Y Zavalij and Volker Briken and Lyle Isaacs},
  journal={Nature chemistry},
  year={2012},
  volume={4 6},
  pages={
          503-10
        }
}
The solubility characteristics of 40-70% of new drug candidates are so poor that they cannot be formulated on their own, so new methods for increasing drug solubility are highly prized. Here, we describe a new class of general-purpose solubilizing agents-acyclic cucurbituril-type containers-which increase the solubility of ten insoluble drugs by a factor of between 23 and 2,750 by forming container-drug complexes. The containers exhibit low in vitro toxicity in human liver, kidney and monocyte… CONTINUE READING
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