Acute yellow oleander (Thevetia peruviana) poisoning: cardiac arrhythmias, electrolyte disturbances, and serum cardiac glycoside concentrations on presentation to hospital

  title={Acute yellow oleander (Thevetia peruviana) poisoning: cardiac arrhythmias, electrolyte disturbances, and serum cardiac glycoside concentrations on presentation to hospital},
  author={Michael Eddleston and Christeine A Ariaratnam and L Sj{\"o}str{\"o}m and S Jayalath and K Rajakanthan and S. Rajapakse and Dinah Gail Colbert and William P. Meyer and Gayathri Perera and S Attapattu and Senanayake A M Kularatne and M H Rezvi Sheriff and David A Warrell},
  pages={301 - 306}
OBJECTIVE To describe the cardiac arrhythmias, electrolyte disturbances, and serum cardiac glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN Case series. SETTING Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral… Expand
Cardiac arrhythmias, electrolyte abnormalities and serum cardiac glycoside concentrations in yellow oleander (Cascabela thevetia) poisoning – a prospective study
Cardiac glycoside concentration at the time of presentation predicted the development of new-onset serious arrhythmia and the independent determinants of mortality were larger number of seeds ingested and hypotension at admission. Expand
Cardiac Manifestations of Thevetia peruviana Poisoning: A Descriptive Study from Northern Sri Lanka
Most of the victims of Yellow oleander poisoning were young adults and the cardiac toxicity developed within 24 hours of ingestion of the seeds. Expand
A Study on Incidence, Clinical Profile and Outcome of Cardiac Dysrhythmias in Yellow Oleander Poisoning
Background: Cardiac toxicity after self-poisoning from ingestion of yellow oleander seeds is a common toxicological emergency in South India. Objectives: The objectives of this study were to identifyExpand
Management of yellow oleander poisoning
Digoxin-specific antibody fragments remain the only proven therapy for yellow oleander poisoning and are effective in reverting life-threatening cardiac arrhythmias in patients with severe poisoning. Expand
Study on clinical profile, electrolyte and electrocardiographic abnormalities in patients with yellow oleander poisoning
Prognosis was poor among those who presented with bradycardia, electrolyte disturbances and complex arrhythmias in patients with yellow oleander poisoning and uniform guidelines have to be formulated. Expand
Cardiac Findings in Acute Yellow Oleander Poisoning
Most of the symptomatic patients had conduction defects affecting sinus or atrio-ventricular nodes but few had atrial or ventricular arrhythmias typical of digoxin poisoning, while patients showing cardiac arrhythms that required specific management had significantly higher serum potassium concentrations. Expand
Cerebra Thevetia poisoning: A prospective study at a tertiary care hospital, Kerala
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In patients with yellow oleander poisoning, dyselectrolytemia with ECG abnormalities was common and having a transvenous temporary pacemaker insertion (TPI) prolonged the duration of hospital stay. Expand
A Study of Clinical, Biochemical and Electrocardiographic aspects of Yellow Oleander Poisoning
Although this study could identify the risk factors for cardiotoxicity, the risk Factors associated with poor outcome could not be well established as the deaths were very few and further studies are required to identify risk factors associated withPoor outcome in this poisoning. Expand
Yellow Oleander Seed Poisoning – A Profile
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Epidemic of self‐poisoning with seeds of the yellow oleander tree (Thevetia peruviana) in northern Sri Lanka
There is an urgent need for an intervention which could be used in rural hospitals, thus preventing the hazardous and expensive emergency transfer of patients to the capital. Expand
A seven‐year total population survey from south‐east Queensland has revealed that, in practice, the rate of clinical poisoning due to oleander is inconsequential, and mortality is negligible. Expand
Yellow oleander poisoning--a study of 170 cases.
170 cases of Thevetia poisoning admitted to the Teaching Hospital, Jaffna in the North of Sri Lanka are studied and the action of the cardiac glycoside in ThevetIA is clearly demonstrated. Expand
The evolving pattern of digoxin intoxication: observations at a large urban hospital from 1980 to 1988.
A retrospective review of medical records of 219 patients discharged with the diagnosis of digoxin intoxication between 1980 and 1988 showed that only four patients were definitely intoxicated, and the diagnosis could not be excluded in another 16 (4%). Expand
Recognition and management of digitalis toxicity.
This drug provides the clinician with a rapidly acting, safe antidote for all commonly used digitalis preparations, and provides a needed safety net for the continuing use of cardiac glycosides as first-line inotropic agents in the modern therapy of chronic CHF. Expand
Oleander toxicity: an examination of human and animal toxic exposures.
Small children and domestic livestock are at increased risk of oleander poisoning, and experimental and established therapeutic measures involved in detoxification are discussed. Expand
Herbal poisoning: a case report of a fatal yellow oleander poisoning from the Solomon Islands.
A fatal yellow oleander herbal poisoning is reported in a 2 1/2-year-old Melanesian boy, who had persistent vomiting,bradycardia caused by complete heart block, hyperkalemia and cardiac glycosidesExpand
Oleander tea: herbal draught of death.
This case demonstrates the cross-reactivity between the cardiac glycosides in oleander and the digoxin radioimmunoassay, and indicates that digoxin-specific Fab antibody fragments might prove to be lifesaving inOleander poisoning. Expand
Deliberate self harm in Sri Lanka: an overlooked tragedy in the developing world
This work has been studying new treatments for self poisoning in Anuradhapura General Hospital, a secondary referral centre for 900 000 people living in the North Central Province of Sri Lanka, and observing at first hand the tragic consequences of suicide for the families and the community. Expand
Yellow oleander poisoning — clinical manifestations and prognostic criteria
  • Ja V na Med J
  • 1985