Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA.

@article{Izumi2004AcuteVR,
  title={Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA.},
  author={Yukitoshi Izumi and Makoto Ishikawa and Ann M. Benz and Masayo Izumi and Charles F Zorumski and Liu Lin Thio},
  journal={Epilepsia},
  year={2004},
  volume={45 9},
  pages={1043-8}
}
PURPOSE Vigabatrin (VGB) is an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase. Its use as an antiepileptic drug (AED) has been limited because it causes retinal dysfunction, leading to visual field defects (VFDs). We performed this study to identify factors contributing to acute VGB retinotoxicity. METHODS In ex vivo experiments, Sprague-Dawley rat retinas were isolated and incubated with VGB or GABA in the presence or absence of light. In in vivo experiments, Sprague… CONTINUE READING

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The Vigabatrin Induced Retinal Toxicity is Associated with Photopic Exposure and Taurine Deficiency: An In Vivo Study.

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