Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure.

@article{Katz2000AcuteT5,
  title={Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure.},
  author={Stuart D Katz and Kujtim Balidemaj and Shunichi Homma and Hongsheng Wu and Jie Wang and Simon Maybaum},
  journal={Journal of the American College of Cardiology},
  year={2000},
  volume={36 3},
  pages={845-51}
}
OBJECTIVES To determine the acute effects of type 5 phosphodiesterase inhibition with sildenafil on flow-mediated vasodilation in the brachial artery of patients with chronic heart failure. BACKGROUND Impaired endothelium-dependent, flow-mediated vasodilation in patients with heart failure is partly attributable to hyporesponsiveness of cyclic guanosine monophosphate (cGMP) mediated vasorelaxation effector mechanisms in vascular smooth muscle. The effect of inhibition of cGMP degradation with… CONTINUE READING
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