Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation.

@article{Rosen2008AcuteTN,
  title={Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation.},
  author={Seymour Rosen and Isaac E Stillman},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2008},
  volume={19 5},
  pages={871-5}
}
Acute tubular necrosis (ATN) is a syndrome of intrinsic renal failure secondary to ischemic or toxic insults. The histopathologic findings of ATN are inconstant. When present, they are limited to the tubulo-interstitium and often subtle despite profound dysfunction. Experimental models of ATN in healthy animals commonly use single insults that result in extensive injury, circumstances that do not parallel the human situation. Recently, there has been a shift to more clinically relevant models… CONTINUE READING

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