Acute tryptophan depletion selectively attenuates cardiac slowing in an Eriksen flanker task

@article{Veen2010AcuteTD,
  title={Acute tryptophan depletion selectively attenuates cardiac slowing in an Eriksen flanker task},
  author={F. M. van der Veen and E. Evers and G. Mies and E. Vuurman and J. Jolles},
  journal={Journal of Psychopharmacology},
  year={2010},
  volume={24},
  pages={1455 - 1463}
}
In the present study, the effects of transiently lowering central serotonin levels by means of acute tryptophan depletion on measures of cognitive flexibility were examined. Flexible behaviour was measured in an Eriksen flanker task, and cardiac and electro-cortical responses to errors and congruent and incongruent stimuli were measured. The depletion was successful in lowering tryptophan levels and, as expected, it did not affect subjective mood. Depletion did not affect performance and… Expand
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References

SHOWING 1-10 OF 48 REFERENCES
Acute tryptophan depletion in healthy males attenuates phasic cardiac slowing but does not affect electro-cortical response to negative feedback
TLDR
Cardiac responses appear to be more sensitive to changes in serotonin metabolism and appear to reflect different aspects of the feedback stimulus, and the phasic cardiac response appears to be an important measure that provides additional information about the impact of feedback stimuli and serotonergic functioning. Expand
The effect of acute tryptophan depletion on the BOLD response during performance monitoring and response inhibition in healthy male volunteers
TLDR
This study provides more evidence for the suggested role of 5-HT in performance monitoring and revealed that gender and personality traits are important variables to take into account for future research. Expand
Serotonin and cognitive flexibility: neuroimaging studies into the effect of acute tryptophan depletion in healthy volunteers.
TLDR
Recent investigations into the effect of ATD on the Blood Oxygen Level Dependent response during tasks that require cognitive flexibility, in healthy volunteers are discussed. Expand
Acute Serotonin and Dopamine Depletion Improves Attentional Control: Findings from the Stroop Task
TLDR
Investigation of the influence of brain monoamine function on Stroop task performance in healthy participants using the established methods of acute dietary serotonin, dopamine, and combined monoamine depletion suggests that reduced tonic dopamine or serotonin activity within specific neural circuits may play a critical role in attentional control. Expand
Acute tryptophan depletion improves performance and modulates the BOLD response during a Stroop task in healthy females
TLDR
The present study showed that a temporary reduction of 5-HT improved Stroop performance and changed the underlying brain activation pattern in healthy female participants and replicated the previous finding that ATD modulated the BOLD response in the dorsomedial prefrontal cortex during tasks that require cognitive control. Expand
Effects of acute tryptophan depletion on executive function in healthy male volunteers
TLDR
The improvement in simple motor speed/ attention following ATD is in keeping with the ascribed role of 5-HT in the cortex, however performance on tests of executive function is not robustly altered. Expand
Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers
TLDR
Results indicate that serotonin is essential in the process of long-term memory consolidation, primarily in the first 30 min after acquisition, and that improvement of specific cognitive processes by lowered 5-HT function may be linked to the removal of inhibitory actions of 5- HT in the cortex. Expand
Acute tryptophan depletion reduces activation in the right hippocampus during encoding in an episodic memory task
TLDR
Results show that serotonin is important in long term memory processes, and that serotonin acts on the encoding phase and not on the retrieval phase. Expand
Neural basis of abnormal response to negative feedback in unmedicated mood disorders
TLDR
The extent to which the amygdala showed less activity during negative feedback correlated inversely with the behavioral tendency to reverse after misleading feedback, which was not present in the MDD group, who also failed to recruit the prefrontal cortex during behavioral reversal. Expand
Acute Tryptophan Depletion in Healthy Volunteers Enhances Punishment Prediction but Does not Affect Reward Prediction
TLDR
The selective potentiation of punishment prediction concurs with recent theorizing, suggesting that central 5-HT carries a prediction error for future punishment, but not for future reward. Expand
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