Acute tryptophan depletion in bulimia: effects on large neutral amino acids.

@article{Weltzin1994AcuteTD,
  title={Acute tryptophan depletion in bulimia: effects on large neutral amino acids.},
  author={Theodore E Weltzin and John D. Fernstrom and Claire W McConaha and Walter H. Kaye},
  journal={Biological psychiatry},
  year={1994},
  volume={35 6},
  pages={388-97}
}
Acute tryptophan depletion, which may reduce brain serotonin synthesis in humans, was evaluated in bulimic and normal subjects assessing its effects on the plasma ratio of tryptophan to the sum of the other large, neutral amino acids (TRP/sigma LNAA). Thirteen bulimic and 9 control women ingested an amino acid mixture containing either 2.3 g (control mixture) or 0 g of tryptophan (active mixture), in combination with 100 g of the other amino acids. Six healthy male volunteers were also studied… CONTINUE READING

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Thirteen bulimic and 9 control women ingested an amino acid mixture containing either 2.3 g ( control mixture ) or 0 g of tryptophan ( active mixture ) , in combination with 100 g of the other amino acids .
An oral , tryptophan - deficient amino acid mixture produced acute , substantial reductions in the plasma TRP / sigma LNAA ratio in all subjects , suggesting that the treatment should reduce brain tryptophan uptake and serotonin synthesis .
An oral , tryptophan - deficient amino acid mixture produced acute , substantial reductions in the plasma TRP / sigma LNAA ratio in all subjects , suggesting that the treatment should reduce brain tryptophan uptake and serotonin synthesis .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
Acute tryptophan depletion in bulimia : effects on large neutral amino acids .
Acute tryptophan depletion , which may reduce brain serotonin synthesis in humans , was evaluated in bulimic and normal subjects assessing its effects on the plasma ratio of tryptophan to the sum of the other large , neutral amino acids ( TRP / sigma LNAA ) .
Acute tryptophan depletion , which may reduce brain serotonin synthesis in humans , was evaluated in bulimic and normal subjects assessing its effects on the plasma ratio of tryptophan to the sum of the other large , neutral amino acids ( TRP / sigma LNAA ) .
Thirteen bulimic and 9 control women ingested an amino acid mixture containing either 2.3 g ( control mixture ) or 0 g of tryptophan ( active mixture ) , in combination with 100 g of the other amino acids .
Acute tryptophan depletion , which may reduce brain serotonin synthesis in humans , was evaluated in bulimic and normal subjects assessing its effects on the plasma ratio of tryptophan to the sum of the other large , neutral amino acids ( TRP / sigma LNAA ) .
Acute tryptophan depletion in bulimia : effects on large neutral amino acids .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
An oral , tryptophan - deficient amino acid mixture produced acute , substantial reductions in the plasma TRP / sigma LNAA ratio in all subjects , suggesting that the treatment should reduce brain tryptophan uptake and serotonin synthesis .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
An oral , tryptophan - deficient amino acid mixture produced acute , substantial reductions in the plasma TRP / sigma LNAA ratio in all subjects , suggesting that the treatment should reduce brain tryptophan uptake and serotonin synthesis .
Thirteen bulimic and 9 control women ingested an amino acid mixture containing either 2.3 g ( control mixture ) or 0 g of tryptophan ( active mixture ) , in combination with 100 g of the other amino acids .
Thirteen bulimic and 9 control women ingested an amino acid mixture containing either 2.3 g ( control mixture ) or 0 g of tryptophan ( active mixture ) , in combination with 100 g of the other amino acids .
Acute tryptophan depletion , which may reduce brain serotonin synthesis in humans , was evaluated in bulimic and normal subjects assessing its effects on the plasma ratio of tryptophan to the sum of the other large , neutral amino acids ( TRP / sigma LNAA ) .
Acute tryptophan depletion , which may reduce brain serotonin synthesis in humans , was evaluated in bulimic and normal subjects assessing its effects on the plasma ratio of tryptophan to the sum of the other large , neutral amino acids ( TRP / sigma LNAA ) .
Acute tryptophan depletion in bulimia : effects on large neutral amino acids .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
An oral , tryptophan - deficient amino acid mixture produced acute , substantial reductions in the plasma TRP / sigma LNAA ratio in all subjects , suggesting that the treatment should reduce brain tryptophan uptake and serotonin synthesis .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
The control mixture did not maintain baseline TRP / sigma LNAA ratios so we identified a control amino acid mixture that does not cause a drop in the plasma TRP / sigma LNAA ratio when ingested ( 4.6 g tryptophan in combination with 100 g of other amino acids ) .
An oral , tryptophan - deficient amino acid mixture produced acute , substantial reductions in the plasma TRP / sigma LNAA ratio in all subjects , suggesting that the treatment should reduce brain tryptophan uptake and serotonin synthesis .
Thirteen bulimic and 9 control women ingested an amino acid mixture containing either 2.3 g ( control mixture ) or 0 g of tryptophan ( active mixture ) , in combination with 100 g of the other amino acids .
Thirteen bulimic and 9 control women ingested an amino acid mixture containing either 2.3 g ( control mixture ) or 0 g of tryptophan ( active mixture ) , in combination with 100 g of the other amino acids .
Acute tryptophan depletion , which may reduce brain serotonin synthesis in humans , was evaluated in bulimic and normal subjects assessing its effects on the plasma ratio of tryptophan to the sum of the other large , neutral amino acids ( TRP / sigma LNAA ) .
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