Acute triiodothyronine administration does not reverse depressed contractile performance following catecholamine exposure in isolated rat cardiomyocytes.

@article{Castell2000AcuteTA,
  title={Acute triiodothyronine administration does not reverse depressed contractile performance following catecholamine exposure in isolated rat cardiomyocytes.},
  author={M. F. Castell and M. Doll and N. Stumpf and C. Vahl and S. Hagl},
  journal={The Thoracic and cardiovascular surgeon},
  year={2000},
  volume={48 1},
  pages={
          27-33
        }
}
  • M. F. Castell, M. Doll, +2 authors S. Hagl
  • Published 2000
  • Medicine
  • The Thoracic and cardiovascular surgeon
  • BACKGROUND It has been previously suggested that triiodothyronine (T3) may reverse depressed cardiac contractile performance occurring after excessive catecholamine stimulation. We therefore investigated the effects of T3 on intracellular calcium transients and contractile performance in isolated ventricular rat myocytes. METHODS Isolated rat myocytes were loaded with the calcium indicator FURA-2/AM (50 micromol/L) and superfused with Krebs-Henseleit solution (pH 7.4). Cells were illuminated… CONTINUE READING
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