Acute toxicity studies of sertaconazole.

Abstract

The acute toxicity of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy- methyl]benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) was evaluated in mice and rats after single administration by oral, subcutaneous and intraperitoneal routes. The latter intended to ensure maximum blood levels, since intravenous route was unfeasible due to drug insolubility in water. LD50 was indeterminable (greater than 8000 mg/kg) in all routes of dosing. According to these results, and having furthermore proved the absorption of the test substance after oral administration, sertaconazole was concluded to be very safe in the event of overdose or accidental ingestion.

Cite this paper

@article{Grau1992AcuteTS, title={Acute toxicity studies of sertaconazole.}, author={Marta Grau and Alejandro Romero and Amelia Sacrist{\'a}n and Julian Arias Ortiz}, journal={Arzneimittel-Forschung}, year={1992}, volume={42 5A}, pages={725-6} }