Acute toxicity oftrans-5-hydroxy-2-nonenal in fisher 344 rats

@article{Nishikawa2006AcuteTO,
  title={Acute toxicity oftrans-5-hydroxy-2-nonenal in fisher 344 rats},
  author={Akiyoshi Nishikawa and Rama S. Sodum and Fung-Lung Chung},
  journal={Lipids},
  year={2006},
  volume={27},
  pages={54-58}
}
The potential toxicity oftrans-4-hydroxy-2-nonenal (HNE), a product formedin vivo during lipid peroxidation, which is also present in foods, was investigated in Fisher 344 rats. Five groups of five male rats each were given by gavage 1000, 300, 100, 30 or 10 mg/kg body weight HNE dissolved in 0.5 mL corn oil. The sixth group, the control, received corn oil alone. Two rats died 6 and 8 hr after being treated with 1000 mg/kg HNE. These two rats showed extensive acute tubular necrosis of the… 

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