Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles.

@article{Cho2009AcuteTA,
  title={Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles.},
  author={Wan-Seob Cho and Minjung Cho and Jinyoung Jeong and Mina Choi and Hea-Young Cho and Beom Seok Han and Sheen Hee Kim and Hyoung Ook Kim and Yong Taik Lim and Bong Hyun Chung and Jayoung Jeong},
  journal={Toxicology and applied pharmacology},
  year={2009},
  volume={236 1},
  pages={16-24}
}
In general, gold nanoparticles are recognized as being as nontoxic. Still, there have been some reports on their toxicity, which has been shown to depend on the physical dimension, surface chemistry, and shape of the nanoparticles. In this study, we carry out an in vivo toxicity study using 13 nm-sized gold nanoparticles coated with PEG (MW 5000). In our findings the 13 nm sized PEG-coated gold nanoparticles were seen to induce acute inflammation and apoptosis in the liver. These nanoparticles… CONTINUE READING