Acute toxicity and genotoxicity of silver nanoparticle in rats

@inproceedings{Wen2017AcuteTA,
  title={Acute toxicity and genotoxicity of silver nanoparticle in rats},
  author={Hairuo Wen and Mo Dan and Ying Yang and Jianjun Lyu and Anliang Shao and Xiang Cheng and Liang Chen and Liming Xu},
  booktitle={PloS one},
  year={2017}
}
OBJECTIVE The potential risk of a nanoparticle as a medical application has raised wide concerns, and this study aims to investigate silver nanoparticle (AgNP)-induced acute toxicities, genotoxicities, target organs and the underlying mechanisms. METHODS Sprague-Dawley rats were randomly divided into 4 groups (n = 4 each group), and AgNP (containing Ag nanoparticles and released Ag+, 5 mg/kg), Ag+ (released from the same dose of AgNP, 0.0003 mg/kg), 5% sucrose solution (vechicle control) and… CONTINUE READING
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