Corpus ID: 38463865

Acute toxicity and cardio-respiratory effects of 2-deoxy-D-glucose: a promising radio sensitiser.

@article{Vijayaraghavan2006AcuteTA,
  title={Acute toxicity and cardio-respiratory effects of 2-deoxy-D-glucose: a promising radio sensitiser.},
  author={Rajagopalan Vijayaraghavan and Deo Nandan Kumar and Shashi N. Dube and Rupesh Singh and K. S. Pandey and Bidhan Chandra Bag and M. P. Kaushik and Khora Samanta Sekhar and Bilikere S Dwarakanath and T Ravindranath},
  journal={Biomedical and environmental sciences : BES},
  year={2006},
  volume={19 2},
  pages={
          96-103
        }
}
OBJECTIVE To evaluate the acute toxicity of 2-deoxy-D-glucose (2DG) by oral (p.o.) and intravenous (i.v.) routes, and also the cardio-respiratory effects following high doses of 2DG in animal models. METHODS The LD50 of 2DG (in water) was determined in rats and mice by p.o. route and in mice by i.v. route. The effect of 2-DG (250 mg/kg, 500 mg/kg, and 1000 mg/kg, i.v.) was studied on various cardio-respiratory parameters viz., mean arterial blood pressure, heart rate and respiratory rate in… Expand
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