Acute toxicity, biochemical and haematological study of Aframomum melegueta seed oil in male Wistar albino rats.

@article{Akpanabiatu2013AcuteTB,
  title={Acute toxicity, biochemical and haematological study of Aframomum melegueta seed oil in male Wistar albino rats.},
  author={M. I. Akpanabiatu and Ndifereke Daniel Ekpo and U. Ufot and Nsikan Malachy Udoh and E. Akpan and E. U. Etuk},
  journal={Journal of ethnopharmacology},
  year={2013},
  volume={150 2},
  pages={
          590-4
        }
}
ETHNOPHARMACOLOGICAL RELEVANCE Aframomum melegueta is a popular medicinal plant in Nigeria believed to have many agents acting in different ways to bring about human health benefits. This study aimed to determine the acute toxicity, identify some phytochemicals known to be present in this plant and the possible effects on lipid profile, haematological indices and biomarker of prostate and cardiac dysfunction. MATERIALS AND METHODS Twenty four Wistar rats (284-326 g) were used in four groups… Expand
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References

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Anti-Inflammatory Activity of Seed Extracts of Aframomum melegueta
TLDR
The study results indicate that seeds of Aframomum melegueta possess potent anti-inflammatory activity with a favorable gastric tolerability profile. Expand
Vitamin E Supplementation with Rauwolfia Vomitoria Root Bark Extract Improves Hematological Indices
TLDR
Rauwolfia vomitoria with or without vitamin E improved animal's immunity and enhances their hematology and interaction of vitamin E with the extract affects medicinal therapeutics of this plant. Expand
Further Evaluation of the Anti–inflammatory Activity of Aframomum Melegueta Seed Extract and its Possible Mechanism of Action
TLDR
The anti–inflammatory effect of aqueous seed extract of Aframomum melegueta (AM) was further evaluated and it was revealed that the membrane stabilizing activity of AM may contribute to its anti-inflammatory action. Expand
Pharmacological Evaluation of the Antidiarrhoeal Activity of Aframomum melegueta Seed Extract
This study presents the pharmacological evaluation of the effects of intraperitoneal injection of aqueous seed extract of Aframomum melegueta (AM) on diarrhoea, intestinal fluid secretion andExpand
Anti-tumor activity of Phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice.
TLDR
The results suggest that P. niruri extract exhibits significant anti-tumor activity, which supports the traditional medicinal utilization of this plant. Expand
The effect of interaction of Rauwolfia vomitoria root bark extract with vitamin E on rats' liver enzymes
TLDR
Histological results confirmed the ameliorating effect of vitamin E on possible toxicity of this herb and concomitant administration of Rauwolfia vomitoria root bark extract with vitamin E may be a better option. Expand
Effects of Phyllanthus Amarus on serum lipid profile and oxidative stressstatus in Salmonellae typhi infested wistar rats
TLDR
The results suggest that treatment of Salmonellae typhi infection with ethanolic extract of Phyllanthus Amarus reduced hyperlipidaemia and lipid peroxidation induced by Salmonella typhi infections in rats. Expand
Androgenic effect of Mondia whitei roots in male rats.
TLDR
Mondia whitei root extract possesses an androgenic property and was found to affect the accessory gland weights, the serum protein contents, the testicular concentration of 17beta -estradiol and the fertility compared to the controls. Expand
Antiplasmodial activity of root extract and fractions of Croton zambesicus.
TLDR
The antiplasmodial activity of this root extract and fractions which is likely to be through peroxidation confirms the folkloric use of this plant. Expand
Anti-prostate cancer activity of a beta-carboline alkaloid enriched extract from Rauwolfia vomitoria.
TLDR
The Rauwolfia vomitoria extract significantly suppressed the growth and cell cycle progression of LNCaP cells, in vitro and in vivo. Expand
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