Corpus ID: 20133757

Acute toxic effects of chloroquine on the cat retina.

@article{Berson1970AcuteTE,
  title={Acute toxic effects of chloroquine on the cat retina.},
  author={E. Berson},
  journal={Investigative ophthalmology},
  year={1970},
  volume={9 8},
  pages={
          618-28
        }
}
  • E. Berson
  • Published 1970
  • Chemistry, Medicine
  • Investigative ophthalmology
Intravitreal administration of 0.5 mg. per 0.1 c.c. of chloroquine hydrochloride produces an irreversible toxic effect to the cat photoreceptors within 40 hours. Of 24 cats that received 0.5 mg. per 0.1 c.c, 19 showed an average reduction of 50 per cent in the amplitude of the electroretinogram (ERG), whereas doses less than 0.5 mg. produced no ERG changes. When the near-threshold dose of 0.5 mg. per 0.1 c.c. is used, the inner retinal layers, examined with the light microscope, appear… Expand
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THE PATHOLOGY OF CHLOROQUINE RETINOPATHY.
Submicroscopic Changes in Visual Cells of the Rabbit Induced by Iodoacetate
OCULAR LESIONS AFTER TREATMENT WITH CHLOROQUINE*
THE OCULAR DEPOSITION OF CHLOROQUINE.
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