Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children

@article{Swanson1999AcuteTT,
  title={Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children},
  author={James Swanson and Suneel K. Gupta and Diane Guinta and Daniel Flynn and Dave Agler and Marc A. Lerner and Lillie Williams and Ira Shoulson and Sharon B. Wigal},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1999},
  volume={66}
}

Evolution of stimulants to treat ADHD: transdermal methylphenidate

The following comprehensive review describes the evolution of stimulant drug formulations used in the treatment of attention‐deficit/hyperactivity disorder (ADHD). Emphasis is placed on the basic and

Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults.

TLDR
This practice parameter describes treatment with stimulant medication, which carries FDA indications for treatment of attention-deficit/hyperactivity disorder and narcolepsy.

Practice Parameter for the Use of Stimulant Medications in the Treatment of Children, Adolescents, and Adults

TLDR
This practice parameter describes treatment with stimulant medication, which carries FDA indications for treatment of attention-deficit/hyperactivity disorder and narcolepsy.

Model-Based Approach for Establishing the Predicted Clinical Response of a Delayed-Release and Extended-Release Methylphenidate for the Treatment of Attention-Deficit/Hyperactivity Disorder

TLDR
This research highlights the need to understand more fully the rationale behind the continued use of these devices, as well as their applications in the field of medicine and sport.

Mechanism of action of agents used in attention-deficit/hyperactivity disorder.

  • T. Wilens
  • Psychology, Biology
    The Journal of clinical psychiatry
  • 2006
TLDR
Elucidating the various mechanisms of action of ADHD medications may lead to better choices in matching potential response to the characteristics (e.g., genotype) of individuals.

Pharmacokinetic Considerations in the Treatment of Attention-Deficit Hyperactivity Disorder with Methylphenidate

TLDR
The difficulties in administering methylphenidate multiple times a day, particularly during the school day, have been alleviated in the past few years by the development of extended-release preparations with varying behavioural effects lasting 8–12 hours.

Methylphenidate blood levels and therapeutic response in children with attention-deficit hyperactivity disorder: I. Effects of different dosing regimens.

TLDR
The rate of absorption and elimination of d- MPH was dependent on the pattern of administration, particularly on the initial bolus concentration, which suggests that d-MPH may act on the gastrointestinal system to slow absorption of additional d-MKH.

Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder.

  • S. Pliszka
  • Psychology, Medicine
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 2007
This practice parameter describes the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder (ADHD) based on the current scientific evidence and clinical

Cognitive and behavioral effects of multilayer-release methylphenidate in the treatment of children with attention-deficit/hyperactivity disorder.

TLDR
MLR MPH given once daily produces equivalent improvements in behavioral and cognitive measures, and has a duration of effect at least as long as that of IR MPH given twice daily.
...

References

SHOWING 1-10 OF 48 REFERENCES

More frequent diagnosis of attention deficit-hyperactivity disorder.

To the Editor: Attention deficit–hyperactivity disorder (ADHD) is considered to be the most common neurobehavioral disorder of childhood,1 but there are no firm estimates of its prevalence. Dramati...

Time-response analysis of the effect of stimulant medication on the learning ability of children referred for hyperactivity.

TLDR
A laboratory learning task is used to document that between one and two hours after the administration of a single dose of methylphenidate, the drug exerts its maximum effect on performance in a learning task in the laboratory.

DRUGS IN MANAGEMENT OF MINIMAL BRAIN DYSFUNCTION

  • J. Millichap
  • Psychology
    Annals of the New York Academy of Sciences
  • 1973
The ideal drug for the treatment of children with minimal brain dysfunction (MBD) should control hyperactivity, increase the span of attention, reduce impulsive and aggressive behavior, and have

Psychopharmacology of attention deficit disorder: pharmacokinetic, neuroendocrine, and behavioral measures following acute and chronic treatment with methylphenidate.

TLDR
The concentration of MPH in single "spot" samples obtained at two to three hours after administration of medication were significantly correlated with the percentage of improvement in the abbreviated Conners rating scale, indicating a relationship between plasma MPH concentration and clinical response.

Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: a comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline.

TLDR
Results revealed generally equivalent and beneficial effects of all four medications, and Dexedrine Spansule and pemoline tended to produce the most consistent effects and were recommended for 10 of the 15 children who were responders to medication.

Sustained release and standard methylphenidate effects on cognitive and social behavior in children with attention deficit disorder.

TLDR
Although group analyses of the data showed that both drugs were effective and there were few differences between them, standard methylphenidate was superior to SR-20 on several important measures of disruptive behavior and analyses of individual responsivity showed clearly that most boys responded more positively to standardethylphenidate than toSR-20.

Methylphenidate in hyperkinetic children: differences in dose effects on learning and social behavior.

TLDR
This study showed a peak enchancement of learning in children after being given a dose of 0.3 milligram per kilogram of body weight, and a decrement in learning in those given larger doses; social behavior showed the most improvement in children given 1.0 milligrams per kilograms.

Absence of tolerance to the behavioral effects of methylphenidate in hyperactive and inattentive children.

The stimulants.

TLDR
Clinical guidelines for the management of children and adolescents receiving stimulants are offered, and treatment strategies are delineated for ADHD subjects with comorbidity and medication-induced adverse effects.

THE EFFECTS OF METHYLPHENIDATE ON SYMPTOMATOLOGY AND LEARNING IN DISTURBED CHILDREN.

TLDR
Objective measures of learning and maze performance and questionnaire measures of initial level of anxiety and impulsivity were not related to symptomatic improvement in the drug group, and some doubt as to the validity of these instruments for the type of children s...