• DOI:10.1038/clpt.1988.104
Corpus ID: 44253676

Acute tolerance to cocaine in humans

@article{Ambre1988AcuteTT,
  title={Acute tolerance to cocaine in humans},
  author={J. Ambre and S. Belknap and J. Nelson and T. Ruo and S. Shin and A. Atkinson},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1988},
  volume={44}
}

• J. Ambre, S. Belknap, +3 authors A. Atkinson
• Published 1988
• Medicine
• Clinical Pharmacology & Therapeutics

There is controversy as to whether acute tolerance develops to the principal effects of cocaine in humans. The studies described here demonstrate the phenomenon of acute tolerance to cocaine chronotropic and subjective effects and the rate and extent of tolerance development. Stable plasma cocaine concentrations were produced and then maintained in volunteer cocaine users by administering an intravenous cocaine injection followed by a cocaine infusion designed to compensate for the plasma… Expand