Acute tolerance to cocaine in humans

@article{Ambre1988AcuteTT,
  title={Acute tolerance to cocaine in humans},
  author={John J. Ambre and Steven M. Belknap and John Nelson and Tsuen Ih Ruo and S‐G Shin and Arthur J. Jr. Atkinson},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1988},
  volume={44}
}
There is controversy as to whether acute tolerance develops to the principal effects of cocaine in humans. The studies described here demonstrate the phenomenon of acute tolerance to cocaine chronotropic and subjective effects and the rate and extent of tolerance development. Stable plasma cocaine concentrations were produced and then maintained in volunteer cocaine users by administering an intravenous cocaine injection followed by a cocaine infusion designed to compensate for the plasma… 
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