Acute therapy with megestrol acetate decreases nuclear and cytosol androgen receptors in human BPH tissue

@article{Geller1982AcuteTW,
  title={Acute therapy with megestrol acetate decreases nuclear and cytosol androgen receptors in human BPH tissue},
  author={Jack Geller and Jerry Albert and S Geller},
  journal={The Prostate},
  year={1982},
  volume={3}
}
This study measures the effect of megestrol acetate (Megace), a progestational antiandrogen, on nuclear and cytosol receptor concentrations in human BPH prostates. Prostatic tissue was obtained at surgery from both untreated patients with BPH and patients pretreated for three to eleven days with 120 to 160 mg of Megace daily; tissues were homogenized and separated into cytosol and crude nuclear fractions. Cytosol and salt extractable nuclear fractions were subjected to saturation analysis with… 
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