Acute therapy with megestrol acetate decreases nuclear and cytosol androgen receptors in human BPH tissue

  title={Acute therapy with megestrol acetate decreases nuclear and cytosol androgen receptors in human BPH tissue},
  author={Jack Geller and Jerry Albert and S Geller},
  journal={The Prostate},
This study measures the effect of megestrol acetate (Megace), a progestational antiandrogen, on nuclear and cytosol receptor concentrations in human BPH prostates. Prostatic tissue was obtained at surgery from both untreated patients with BPH and patients pretreated for three to eleven days with 120 to 160 mg of Megace daily; tissues were homogenized and separated into cytosol and crude nuclear fractions. Cytosol and salt extractable nuclear fractions were subjected to saturation analysis with… 
, In Serum of a Patientwith Cancer of the Prostate
Characterization of unoccupied (R) and occupied (RA) androgen binding components of the hyperplastic human prostate and the role of nuclear and cytosol androgen receptor in human BPH tissue are described.
Overview of enzyme inhibitors and anti-androgens in prostatic cancer.
  • J. Geller
  • Medicine, Biology
    Journal of andrology
  • 1991
Large-scale, multicenter, double-blind studies were done in the 1980s to compare the effect of combined androgen blockade, using multiple drugs, to single-drug blockade of gonadal androgen with regard to time to progression and survival in stage D2 cancer.
Tissue dihydrotestosterone levels and clinical response to hormonal therapy in patients with advanced prostate cancer.
The thesis that tissue DHT levels may be a useful marker for predicting the clinical response of prostate cancer to antiandrogen therapy is supported.
Cellular Growth and Hormone Receptors
The hormonal mechanisms related to normal and neoplastic growth of cellular and stromal compartments of the prostate have been the subject of numerous studies, many of which have been based on
The type of current frequency used in transurethral resection of prostate (TURP) affects the androgen receptor
The androgen receptor method used is highly reliable for prostate obtained by either open resection or electroresection using pure cutting currents, although receptor concentrations in samples obtained by the two methods probably should not be combined or compared.
Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects
Some recent studies of the potential involvement of progesterone and related compounds in HCC from basic and clinical aspects are collected and a new insight is suggested on the associations of progestersone andrelated compounds with HCC development and treatment.
Editorial: Megestrol acetate use for weight gain should be carefully considered.
  • W. Evans
  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 2007
It is demonstrated, once again, that MA has a substantial effect on appetite and body weight, with fat gain the principal component of the increase in body weight.


Effect of megestrol acetate (Megace) on steroid metabolism and steroid-protein binding in the human prostate.
Megestrol acetate (Megace), an antiandrogen, was administered in a dosage of 80 mg daily to 6 patients with benign prostatic hypertrophy (BPH) for 4 to 25 days prior to transurethral resection of the
Regulation of cytoplasmic dihydrotestosterone binding in dog prostate by 17 beta-estradiol.
Enhancement by 17 beta-estradiol of a prostate cytosol androgen-binding protein occurs under circumstances in which 17 Beta-ESTradiol enhances androgens-mediated prostatic growth.
Progesterone action in hamster uterus: rapid inhibition of 3H-estradiol retention by the nuclear fraction.
Results indicate that P reduction of uterine nuclear Re results from the P-stimulated loss of Re from the nuclear fraction and not by the inhibition of cytosol Re translocation.
Androgen receptor in human skin cytosol.
The parity of values in genital skin from men and women, the absence of variation with age, and the presence of a cytosolic androgens receptor in some androgen-insensitive patients suggest that the androgen receptor in human skin cytosol is not regulated by androgens.
The ontogeny of the androgen receptor in human foreskin.
It is suggested that changes in the intracellular distribution of androgen receptor may bear some relationship to the sequence of normal genital growth and development with nuclear androgen receptors having major physiological importance.