Acute therapy with megestrol acetate decreases nuclear and cytosol androgen receptors in human BPH tissue

@article{Geller1982AcuteTW,
  title={Acute therapy with megestrol acetate decreases nuclear and cytosol androgen receptors in human BPH tissue},
  author={Jack Geller and Jerry Albert and S Geller},
  journal={The Prostate},
  year={1982},
  volume={3}
}
This study measures the effect of megestrol acetate (Megace), a progestational antiandrogen, on nuclear and cytosol receptor concentrations in human BPH prostates. Prostatic tissue was obtained at surgery from both untreated patients with BPH and patients pretreated for three to eleven days with 120 to 160 mg of Megace daily; tissues were homogenized and separated into cytosol and crude nuclear fractions. Cytosol and salt extractable nuclear fractions were subjected to saturation analysis with… 
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19 Citations
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19 Citations

Effects of two different medical treatments on dihydrotestosterone content and androgen receptors in human benign prostatic hyperplasia.
Tamoxifen decreases progesterone and nuclear androgen receptors in the human prostate.
, In Serum of a Patientwith Cancer of the Prostate
TLDR
Characterization of unoccupied (R) and occupied (RA) androgen binding components of the hyperplastic human prostate and the role of nuclear and cytosol androgen receptor in human BPH tissue are described.
Overview of enzyme inhibitors and anti-androgens in prostatic cancer.
  • J. Geller
  • Medicine, Biology
    Journal of andrology
  • 1991
TLDR
Large-scale, multicenter, double-blind studies were done in the 1980s to compare the effect of combined androgen blockade, using multiple drugs, to single-drug blockade of gonadal androgen with regard to time to progression and survival in stage D2 cancer.
Tissue dihydrotestosterone levels and clinical response to hormonal therapy in patients with advanced prostate cancer.
TLDR
The thesis that tissue DHT levels may be a useful marker for predicting the clinical response of prostate cancer to antiandrogen therapy is supported.
Effects of megestrol acetate on pituitary function and end-organ hormone secretion: a post hoc analysis of serum samples from a 12-week study in healthy older men.
Cellular Growth and Hormone Receptors
The hormonal mechanisms related to normal and neoplastic growth of cellular and stromal compartments of the prostate have been the subject of numerous studies, many of which have been based on…
The type of current frequency used in transurethral resection of prostate (TURP) affects the androgen receptor
TLDR
The androgen receptor method used is highly reliable for prostate obtained by either open resection or electroresection using pure cutting currents, although receptor concentrations in samples obtained by the two methods probably should not be combined or compared.
Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects
TLDR
Some recent studies of the potential involvement of progesterone and related compounds in HCC from basic and clinical aspects are collected and a new insight is suggested on the associations of progestersone andrelated compounds with HCC development and treatment.
Editorial: Megestrol acetate use for weight gain should be carefully considered.
  • W. Evans
  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 2007
TLDR
It is demonstrated, once again, that MA has a substantial effect on appetite and body weight, with fat gain the principal component of the increase in body weight.
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