Acute therapy with megestrol acetate decreases nuclear and cytosol androgen receptors in human BPH tissue

@article{Geller1982AcuteTW,
  title={Acute therapy with megestrol acetate decreases nuclear and cytosol androgen receptors in human BPH tissue},
  author={J. Geller and J. Albert and S. Geller},
  journal={The Prostate},
  year={1982},
  volume={3}
}
This study measures the effect of megestrol acetate (Megace), a progestational antiandrogen, on nuclear and cytosol receptor concentrations in human BPH prostates. Prostatic tissue was obtained at surgery from both untreated patients with BPH and patients pretreated for three to eleven days with 120 to 160 mg of Megace daily; tissues were homogenized and separated into cytosol and crude nuclear fractions. Cytosol and salt extractable nuclear fractions were subjected to saturation analysis with… Expand
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References

SHOWING 1-10 OF 12 REFERENCES
Effect of megestrol acetate (Megace) on steroid metabolism and steroid-protein binding in the human prostate.
Regulation of cytoplasmic dihydrotestosterone binding in dog prostate by 17 beta-estradiol.
Progesterone action in hamster uterus: rapid inhibition of 3H-estradiol retention by the nuclear fraction.
Androgen receptors in the rat epididymis do not disappear after castration.
Evidence for an androgen-independent mechanism regulating the levels of receptor in target tissue.
Evaluation of the use of cyproterone acetate competition to distinguish between high-affinity binding of [3H]-dihydrotestosterone to human prostate cytosol receptors and to sex hormone-binding globulin.
Androgen receptor in human skin cytosol.
The ontogeny of the androgen receptor in human foreskin.
Characterization of unoccupied (R) and occupied (RA) androgen binding components of the hyperplastic human prostate
Androgen receptors in the rat ventral prostate and their hormonal control.
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