Acute suppression of spontaneous neurotransmission drives synaptic potentiation.

  title={Acute suppression of spontaneous neurotransmission drives synaptic potentiation.},
  author={Elena D. Nosyreva and Kristen Szabla and Anita E. Autry and Alexey G. Ryazanov and Lisa M Monteggia and Ege T Kavalali},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={33 16},
The impact of spontaneous neurotransmission on neuronal plasticity remains poorly understood. Here, we show that acute suppression of spontaneous NMDA receptor-mediated (NMDAR-mediated) neurotransmission potentiates synaptic responses in the CA1 regions of rat and mouse hippocampus. This potentiation requires protein synthesis, brain-derived neurotrophic factor expression, eukaryotic elongation factor-2 kinase function, and increased surface expression of AMPA receptors. Our behavioral studies… CONTINUE READING
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