Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance

@article{Adiels2007AcuteSO,
  title={Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance},
  author={Martin Adiels and Jukka Westerbacka and Aino Soro-Paavonen and A. M. H{\"a}kkinen and Satu Vehkavaara and Muriel J. Caslake and Chris Packard and S. O. Olofsson and Hannele Yki-J{\"a}rvinen and M. R. Taskinen and Jan Bor{\'e}n},
  journal={Diabetologia},
  year={2007},
  volume={50},
  pages={2356-2365}
}
Overproduction of VLDL1 seems to be the central pathophysiological feature of the dyslipidaemia associated with type 2 diabetes. We explored the relationship between liver fat and suppression of VLDL1 production by insulin in participants with a broad range of liver fat content. A multicompartmental model was used to determine the kinetic parameters of apolipoprotein B and TG in VLDL1 and VLDL2 after a bolus of [2H3]leucine and [2H5]glycerol during a hyperinsulinaemic–euglycaemic clamp in 20… CONTINUE READING

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