Acute supplementation of N‐acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise

  title={Acute supplementation of N‐acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise},
  author={Joshua R Smith and Ryan M. Broxterman and Carl J. Ade and Kara K Evans and Stephanie P Kurti and Shane M Hammer and Thomas Barstow and Craig A Harms},
  journal={Physiological Reports},
N‐acetylcysteine (NAC; antioxidant and thiol donor) supplementation has improved exercise performance and delayed fatigue, but the underlying mechanisms are unknown. One possibility is NAC supplementation increases limb blood flow during severe‐intensity exercise. The purpose was to determine if NAC supplementation affected exercising arm blood flow and muscle oxygenation characteristics. We hypothesized that NAC would lead to higher limb blood flow and lower muscle deoxygenation… Expand
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N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals.
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N‐acetylcysteine attenuates the decline in muscle Na+,K+‐pump activity and delays fatigue during prolonged exercise in humans
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