Acute supplementation of N‐acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise

@article{Smith2016AcuteSO,
  title={Acute supplementation of N‐acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise},
  author={Joshua R Smith and Ryan M. Broxterman and Carl J. Ade and Kara K Evans and Stephanie P Kurti and Shane M Hammer and Thomas Barstow and Craig A Harms},
  journal={Physiological Reports},
  year={2016},
  volume={4}
}
N‐acetylcysteine (NAC; antioxidant and thiol donor) supplementation has improved exercise performance and delayed fatigue, but the underlying mechanisms are unknown. One possibility is NAC supplementation increases limb blood flow during severe‐intensity exercise. The purpose was to determine if NAC supplementation affected exercising arm blood flow and muscle oxygenation characteristics. We hypothesized that NAC would lead to higher limb blood flow and lower muscle deoxygenation… Expand
The effect of chronic soluble keratin supplementation in physically active individuals on body composition, blood parameters and cycling performance
TLDR
The data suggest that KER is not useful as an ergogenic aid for endurance athletes but may be a suitable protein supplement for maximizing increases in lean body mass. Expand
Effect of cyclooxygenase inhibition on the inspiratory muscle metaboreflex-induced cardiovascular consequences in men.
TLDR
It is demonstrated that COX inhibition led to greater increases in blood pressure and limb vascular resistance compared with placebo during inspiratory muscle metaboreflex activation. Expand
Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights
TLDR
A background to endurance exercise-related redox signalling and the subsequent adaptations in skeletal muscle and vascular function is provided and the lack of supportive evidence for most antioxidant compounds to recommend to athletes is highlighted. Expand
The noninvasive simultaneous measurement of tissue oxygenation and microvascular hemodynamics during incremental handgrip exercise.
TLDR
It is demonstrated that indices of perfusive and diffusive microvascular oxygen transport to skeletal muscle, measured completely noninvasively, plateau at submaximal work rates during incremental exercise, even though limb blood flow and muscle recruitment continued to increase. Expand
Sex differences in the cardiovascular consequences of the inspiratory muscle metaboreflex.
TLDR
Data indicate premenopausal women exhibit an attenuated inspiratory muscle metaboreflex compared with age-matched men, and sex differences in MAP, Q̇L, and LVR were still present in a subset of subjects matched for PIMAX. Expand
Sport nutrition, redox homeostasis and toxicity in sport performance
TLDR
It seems that exercise could positively influence the human gut microbiota composition by increasing diversity and favouring the increase of relative abundances of health-promoting microbial species. Expand
Cardiovascular consequences of the inspiratory muscle metaboreflex: effects of age and sex.
TLDR
The data suggest that OW exhibit a greater inspiratory muscle metaboreflex compared with YW, whereas no differences between OM and YM existed, and sex differences in the inspiratory Muscle Metabolflex are not present in older adults. Expand
The Physiological Effects of N-Acetylcysteine in Clinical Studies
The previous chapters in this book have presented the empirical studies demonstrating the therapeutic effect of N-acetylcysteine (NAC) on various disease processes. For many diseases, the proposedExpand
Microvascular blood flow during vascular occlusion tests assessed by diffuse correlation spectroscopy
TLDR
Skeletal muscle blood flow was significantly slower than the transient increase in the cutaneous tissue, suggesting mechanistic differences between cutaneous and muscular blood flow distribution after transient ischaemia. Expand

References

SHOWING 1-10 OF 52 REFERENCES
N-acetylcysteine infusion alters blood redox status but not time to fatigue during intense exercise in humans.
TLDR
NAC infusion altered blood redox status during intense, intermittent exercise but did not attenuate fatigue, and increased the rise in plasma K(+) concentration-to-work ratio, indicating impaired K(+, regulation. Expand
Effects of intravenous N-acetylcysteine infusion on time to fatigue and potassium regulation during prolonged cycling exercise.
TLDR
Time to fatigue was reproducible in preliminary trials and time to fatigue during NAC trials was correlated with Vo2 peak, suggesting that NAC effects on performance may be dependent on training status, and possible training status-dependent effect of NAC on muscle performance and K+ regulation. Expand
Effects of N‐acetylcysteine on glutathione oxidation and fatigue during handgrip exercise
TLDR
The data indicate that NAC supports glutathione homeostasis in exercising humans and may delay muscle fatigue during repetitive handgrip exercise and argue for larger translational studies to define NAC effects on human performance. Expand
N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals.
TLDR
NAC improved performance in well-trained individuals, with enhanced muscle cysteine and GSH availability a likely mechanism. Expand
N‐acetylcysteine attenuates the decline in muscle Na+,K+‐pump activity and delays fatigue during prolonged exercise in humans
TLDR
It is confirmed that the antioxidant NAC attenuates muscle fatigue, in part via improved K+ regulation, and point to a role for ROS in muscle fatigue. Expand
Influence of N-acetylcysteine administration on pulmonary O2 uptake kinetics and exercise tolerance in humans
TLDR
The results suggest that exercise-induced redox perturbations may contribute to fatigue development in recreationally-active adults. Expand
N-acetylcysteine alters substrate metabolism during high-intensity cycle exercise in well-trained humans.
TLDR
It is suggested that NAC alters substrate metabolism and muscle fibre type recruitment during HIIE, which is detrimental to time-trial performance. Expand
Effects of N-acetylcysteine on respiratory muscle fatigue during heavy exercise
TLDR
It is suggested that an acute dose of NAC reduces RMF during heavy exercise, suggesting that oxidative stress is a contributing factor. Expand
N-acetylcysteine in handgrip exercise: plasma thiols and adverse reactions.
TLDR
NAC effects on plasma thiols are maximized by oral administration of 70 mg/kg, a dose that does not cause significant adverse reactions and is directly related to handgrip exercise performance. Expand
Effect of N-acetylcysteine on cycling performance after intensified training.
TLDR
Oral NAC supplementation improved cycling performance via an improved redox balance and promoted adaptive processes in well-trained athletes undergoing strenuous physical training. Expand
...
1
2
3
4
5
...