Acute supplementation of N‐acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise

@article{Smith2016AcuteSO,
  title={Acute supplementation of N‐acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise},
  author={Joshua R. Smith and R. Broxterman and C. Ade and K. Evans and S. Kurti and Shane M Hammer and T. Barstow and C. Harms},
  journal={Physiological Reports},
  year={2016},
  volume={4}
}
  • Joshua R. Smith, R. Broxterman, +5 authors C. Harms
  • Published 2016
  • Medicine
  • Physiological Reports
  • N‐acetylcysteine (NAC; antioxidant and thiol donor) supplementation has improved exercise performance and delayed fatigue, but the underlying mechanisms are unknown. One possibility is NAC supplementation increases limb blood flow during severe‐intensity exercise. The purpose was to determine if NAC supplementation affected exercising arm blood flow and muscle oxygenation characteristics. We hypothesized that NAC would lead to higher limb blood flow and lower muscle deoxygenation… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 52 REFERENCES
    N‐acetylcysteine attenuates the decline in muscle Na+,K+‐pump activity and delays fatigue during prolonged exercise in humans
    • 236
    • Highly Influential
    • Open Access
    N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals.
    • 197
    • Highly Influential
    • Open Access
    Effects of intravenous N-acetylcysteine infusion on time to fatigue and potassium regulation during prolonged cycling exercise.
    • 90
    • Highly Influential
    • Open Access
    Effects of N‐acetylcysteine on glutathione oxidation and fatigue during handgrip exercise
    • 130
    • Highly Influential
    Effects of N-acetylcysteine on respiratory muscle fatigue during heavy exercise
    • 49
    • Open Access
    Effect of N-acetylcysteine on human diaphragm strength and fatigability.
    • 115
    • Highly Influential
    Muscle oxygenation and pulmonary gas exchange kinetics during cycling exercise on-transitions in humans.
    • 371
    • Open Access