Acute studies of a new primate model of reversible middle cerebral artery occlusion.

@article{Crespigny2005AcuteSO,
  title={Acute studies of a new primate model of reversible middle cerebral artery occlusion.},
  author={Alex J. de Crespigny and Helen D'Arceuil and Kenneth I. Maynard and Julian He and Dan McAuliffe and Alexander Norbash and Prabhat K. Sehgal and Leena Hamberg and George Hunter and Ronald F Budzik and Christopher M. Putman and R. Gilberto Gonzalez},
  journal={Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association},
  year={2005},
  volume={14 2},
  pages={80-7}
}
The recent failure of many clinical trials of neuroprotective compounds may be due in part to poor animal models of human stroke. We have developed an endovascular stroke model in nonhuman primates that is compatible with serial magnetic resonance imaging (MRI) monitoring. Using cynomologous macaques (n = 4), a microcatheter was navigated transarterially (under fluoroscopic guidance) from the femoral artery to the middle cerebral artery (MCA). The microcatheter was wedged in a branch of the MCA… CONTINUE READING

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