Acute stress diminishes M-current contributing to elevated activity of hypothalamic-pituitary-adrenal axis.

@article{Zhou2017AcuteSD,
  title={Acute stress diminishes M-current contributing to elevated activity of hypothalamic-pituitary-adrenal axis.},
  author={Jing-Jing Zhou and Yonggang Gao and Therese A. Kosten and Zongmao Zhao and De-Pei Li},
  journal={Neuropharmacology},
  year={2017},
  volume={114},
  pages={
          67-76
        }
}
Acute stress stimulates corticotrophin-releasing hormone (CRH)-expressing neurons in the hypothalamic paraventricular nucleus (PVN), which is an essential component of hypothalamic-pituitary-adrenal (HPA) axis. However, the cellular and molecular mechanisms remain unclear. The M-channel is a voltage-dependent K+ channel involved in stabilizing the neuronal membrane potential and regulating neuronal excitability. In this study, we tested our hypothesis that acute stress suppresses expression of… CONTINUE READING