Acute silica toxicity: attenuation by amiodarone-induced pulmonary phospholipidosis.

  title={Acute silica toxicity: attenuation by amiodarone-induced pulmonary phospholipidosis.},
  author={James M· Antonini and Christy McCloud and Mark J. Reasor},
  journal={Environmental Health Perspectives},
  pages={372 - 378}
Exposure to the toxic mineral dust silica has been shown to produce an acute inflammatory response in the lungs of both humans and laboratory animals. Coating silica with phospholipids reduces its toxicity when studied with in vitro systems. The drug amiodarone increases phospholipid within the cells, airways, and alveoli of the lungs. This increase in phospholipid is due to amiodarone's ability to inhibit phospholipase activity within alveolar macrophages (AMs) and whole lung. The purpose of… CONTINUE READING
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