Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat.

@article{Khan2000AcuteSE,
  title={Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat.},
  author={Wasiuddin A. Khan and Anjelika M. Dechkovskaia and Erin Herrick and Katherine Heard Jones and Mohamed Bahie Abou-Donia},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2000},
  volume={57 1},
  pages={112-20}
}
Acute neurotoxic effects of sarin (O:-isopropylmethylphosphonoflouridate) in male Sprague-Dawley rats were studied. The animals were treated with intramuscular (im) injections of either 1 x LD(50) (100 microg/kg), and sacrificed at 0. 5, 1, 3, 6, 15, or 20 h after treatment, or with im injections of either 0.01, 0.1, 0.5, or 1 x LD(50) and sacrificed 15 h after treatment. Plasma butyrylcholinesterase (BChE) and brain regional acetylcholinesterase (AChE) were inhibited (45-55%) by 30 min after… CONTINUE READING

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