Acute rheumatic fever

@article{Karthikeyan2018AcuteRF,
  title={Acute rheumatic fever},
  author={Ganesan Karthikeyan and Luiza Guilherme},
  journal={The Lancet},
  year={2018},
  volume={392},
  pages={161-174}
}
Acute rheumatic fever is caused by an autoimmune response to throat infection with Streptococcus pyogenes. Cardiac involvement during acute rheumatic fever can result in rheumatic heart disease, which can cause heart failure and premature mortality. Poverty and household overcrowding are associated with an increased prevalence of acute rheumatic fever and rheumatic heart disease, both of which remain a public health problem in many low-income countries. Control efforts are hampered by the… Expand
24 Citations
Rheumatic Fever and Rheumatic Heart Disease in Children
TLDR
The focus of management has been on prompt recognition and treatment of streptococcal pharyngitis and preventing recurrences of ARF with long-term antibiotic prophylaxis, but emphasis should be placed on the appropriate management of patients with established RHD, in order to limit the RHD related mortality. Expand
Acute Rheumatic Fever
TLDR
Clinicians need to be aware of the clinical signs and symptoms of ARF to include in their differential diagnosis when seeing such patients, and understand the implications of secondary prophylaxis for ARF. Expand
Incidence of acute rheumatic fever in northern and western Uganda: a prospective, population-based study.
BACKGROUND Acute rheumatic fever is infrequently diagnosed in sub-Saharan African countries despite the high prevalence of rheumatic heart disease. We aimed to determine the incidence of acuteExpand
Rheumatic heart disease: A review of the current status of global research activity.
TLDR
This review will focus on the epidemiology, pathogenesis and treatment of ARF and RHD in Australia, where streptococcal pyoderma, rather than strePTococcal pharyngitis, and Group C and Group G Streptococcus, have been implicated as antecedents to ARF. Expand
Epidemiology, Risk Factors, Burden and Cost of Acute Rheumatic Fever and Rheumatic Heart Disease
TLDR
The majority of disease risk is conferred by environmental and social factors, including poor-quality housing and household crowding, poor nutrition, and low use of preventive health services. Expand
Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms
TLDR
This review focuses on pathophysiology and underlying mechanisms of RHVD, and suggests that pathological mechanisms have been already proposed for RHVD but none of them are able to explain the preferential involvement of the mitral valve. Expand
Unusual presentation of rheumatic fever in a 3-year-old child in the UK
TLDR
The need to be vigilant for the presentation of a rare illness, such as rheumatic fever, as there can be significant impacts on the quality of life of young patients is illustrated. Expand
Acute Rheumatic Fever: Where Do We Stand? An Epidemiological Study in Northern Italy
TLDR
In the Province of Monza-Brianza, Italy, an incidence rate of ARF among children aged 5–14 years constantly above the threshold of low-risk area as defined in the 2015 revision of Jones criteria is found. Expand
A case report of isolated rheumatic tricuspid regurgitation and pericarditis
TLDR
The case of a 16-year-old male patient who developed upper respiratory tract infection followed by typical pericarditis chest pain is presented and it is highlighted that the physical and lab findings of rheumatic TR are similar to those of Rheumatic mitral regurgitation, with the exception of a high-velocity jet. Expand
Detecting sub-clinical disease activity in patients with chronic rheumatic valvular heart disease
TLDR
Conventional inflammatory markers are elevated in the majority, but aren’t discriminatory enough to identify the presence of histologic inflammation, and sub-clinical inflammation is common in RHD patients. Expand
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