Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes.

@article{Chan2015AcuteRO,
  title={Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes.},
  author={Y L Chan and Wei-Chung Tsai and Zhen Guo Song and Christopher Y. Ko and Zhilin Qu and James N. Weiss and Shien-Fong Lin and Peng-Sheng Chen and Larry R. Jones and Zhenhui Chen},
  journal={Journal of molecular and cellular cardiology},
  year={2015},
  volume={80},
  pages={126-35}
}
Phospholamban (PLB) inhibits the activity of cardiac sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a). Phosphorylation of PLB during sympathetic activation reverses SERCA2a inhibition, increasing SR Ca(2+) uptake. However, sympathetic activation also modulates multiple other intracellular targets in ventricular myocytes (VMs), making it impossible to… CONTINUE READING