Acute responses to estradiol replacement in the olfactory system of apoE-deficient and wild-type mice

@article{Nathan2010AcuteRT,
  title={Acute responses to estradiol replacement in the olfactory system of apoE-deficient and wild-type mice},
  author={Britto P Nathan and Michael Tonsor and Robert G. Struble},
  journal={Brain Research},
  year={2010},
  volume={1343},
  pages={66-74}
}
Epidemiological studies suggest that estrogen therapy protects against clinical expression of chronic neurological diseases. These beneficial effects of estrogen therapy are highly modified by apolipoprotein E (apoE) through an unknown mechanism. We examined the short-term effects of estradiol replacement in ovariectomized mice on apoE expression and markers for cell proliferation, reactive gliosis, neuronal maturation, and synaptogenesis in the primary olfactory pathway of wild-type (WT) and… CONTINUE READING

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