Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature

  title={Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature},
  author={Ming-shen Dai and C. L. Ho and Y. C. Chen and W. Y. Kao and Tsu Yi Chao},
  journal={Annals of Hematology},
Abstract Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms… 
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